A Multi-Omics Human Liver Organoid Screening Platform for DILI Risk Prediction
Drug-induced liver injury (DILI) is a prominent failure mode in drug development resulting in clinical trial failures and post-approval [...]
Drug-induced liver injury (DILI) is a prominent failure mode in drug development resulting in clinical trial failures and post-approval [...]
Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also [...]
In this manuscript, we evaluated the efficacy of Lactoferrin against several SARS-CoV-2 variants of concern. Lactoferrin showed strong efficacy [...]
The effect of ultraviolet C radiation against different N95 respirators inoculated with SARS-CoV-2 Objectives: There are currently no studies that [...]
SARS-CoV-2 receptor networks in diabetic and COVID-19–associated kidney disease: COVID-19 morbidity and mortality are increased via unknown mechanisms in [...]
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity (‘‘nuisance compounds’’) are routinely encountered in cellular assays, including [...]
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2 This study is published in PNAS and details the role the Ace2 [...]
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 In this study, we used high content [...]
In a collaborative effort, the Sexton lab helped to quantitate cellular morphologies to establish that Hic-5 regulates vimentin organization [...]
Group photo of our High Content bootcamp in Utrecht, Netherlands.