Human Norovirus Efficiently Replicates in Differentiated 3D-Human Intestinal Enteroids
Human norovirus (HNoV) accounts for one-fifth of all acute viral gastroenteritis worldwide and an economic burden of ~$60 billion [...]
August 2023
Imaging-Based Screening Identifies Modulators of the eIF3 Translation Initiation Factor Complex in Candida albicans
Fungal pathogens like Candida albicans can cause devastating human disease. Treatment of candidemia is complicated by the high rate [...]
Automated high-throughput, high-content 3D imaging of intact pancreatic islets
Diabetes poses a global health crisis affecting individuals across age groups and backgrounds, with a prevalence estimate of 700 [...]
A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects
Neural tube defects (NTDs), including anencephaly and spina bifida, are common major malformations of fetal development resulting from incomplete [...]
Proxalutamide reduces SARS-CoV-2 infection and associated inflammatory response
Early in the COVID-19 pandemic, data suggested that males had a higher risk of developing severe disease and that [...]
Single-Cell, High-Content Microscopy Analysis of BK Polyomavirus Infection
By adulthood, the majority of the population is persistently infected with BK polyomavirus (BKPyV). Only a subset of the [...]
Machine Learning and Assay Development for Image-based Phenotypic Profiling of Drug Treatments
High content imaging produces significant volumes of data on individual cells. The number of discrete measurements per cell can [...]
June 2022
A Multi-Omics Human Liver Organoid Screening Platform for DILI Risk Prediction
Drug-induced liver injury (DILI) is a prominent failure mode in drug development resulting in clinical trial failures and post-approval [...]
In Vitro Evaluation and Mitigation of Niclosamide’s Liabilities as a COVID-19 Treatment
Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also [...]
March 2022
Evaluating the in vitro efficacy of bovine lactoferrin products against SARS-CoV-2 variants of concern
In this manuscript, we evaluated the efficacy of Lactoferrin against several SARS-CoV-2 variants of concern. Lactoferrin showed strong efficacy [...]